Oxidative stress indices in rats’ lung tissues following simultaneous exposure to noise and styrene
نویسندگان
چکیده مقاله:
Background: Simultaneous exposure to noise and organic solvents such as styrene is an indispensable part of today’s industries. Numerous studies were done related to ototoxic effects of co-exposure to noise and styrene while some evidences showed the adverse effects of such exposure on other organs. In this study, we aimed to assess the subacute effects of combined exposure to noise and styrene on rats’ lung tissue. Materials and Methods: Twenty-four Wistar male rats were divided in four groups including: A) control, B) rats exposed to 100 dB octave band of noise, C) rats exposed to 750 ppm styrene alone, and D) rats exposed to combination of 100 dB noise and 750 ppm styrene. Following the last day of exposure, the rats were euthanized and their lung tissues were excised, homogenized and assayed for biological analysis of malondialdehyde (MDA), glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD). The results were analyzed using SPSS software. Results: MDA increased significantly (P < 0.001) at the end of experiment in the group exposed to styrene and noise-styrene. GSH concentrations decreased significantly in styrene and noise-styrene group (P < 0.001). SOD (P < 0.001) and CAT (P < 0.05) activities were determined to be significantly lower for the styrene and noise-styrene groups compared to the control group. Conclusions: In conclusion, our results indicated that exposure to combination of noise and styrene caused oxidative stress, increased lipid peroxidation, and antioxidant depletion. These results appear to support the fact that co-exposure to noise and styrene might cause oxidative stress-induced damage to the lung tissue. Since simultaneous exposure to noise and styrene has an additive effect in this regard, further studies are necessary to be carried out on the effects of noise and organic solvents co-exposure.
منابع مشابه
Effects of simultaneous exposure to noise and styrene on rat liver enzymes
Background: Liver is an important organ that responsible for biological detoxification. There are few studies about the effect of co-exposure to organic solvents and noise on hepatic system enzymes. The study aim was to assess the effects of short-term exposure to noise and styrene on rat liver enzymes. Materials and Methods: In this experimental study, we studied the liver enzymes of male r...
متن کاملHistological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats
Background and purpose: Stressful events in early-life induce metabolic disorders in adolescence. The aim of this study was to investigate the effect of early-life stress on number or area of Langerhans islets in exposure to foot-shock and psychological stress in male rats. Materials and methods: The rats were divided into six groups: control (without stress), early-stress (stress at 2 weeks o...
متن کاملradiation-induced oxidative stress at out-of-field lung tissues after pelvis irradiation in rats
objective: the out-of-field/non-target effect is one of the most important phenomena of ionizing radiation that leads to molecular and cellular damage to distant non-irradiated tissues. the most important concern about this phenomenon is carcinogenesis many years after radiation treatment. in vivo mechanisms and consequences of this phenomenon are not known completely. therefore, this study aim...
متن کاملTime course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats
Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI). Materials ...
متن کاملHearing impairment due to cigarette smoking and simultaneous exposure to occupational noise
Abstract Background : Noise is the most common hazard in the workplace and noise induced hearing loss considered to be the most common occupational disease as well. Cigarette smoking, in some studies, has been known to induce hearing loss. The purpose of this study was to evaluate the effect of contemporary exposure to occupational noise and cigarette smoking on hearing. Methods :...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 6 شماره 1
صفحات 1- 8
تاریخ انتشار 2017-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023